Sox4 chip
Web为了了解sox4在动脉粥样硬化中的作用，在wd喂养前，将内皮特异性aav-sox4注射到apoe−/− 小鼠。结果表明，sox4过表达增加了apoe−/− 小鼠主动脉中sox4蛋白的表达（图2 a）。sox4过表达增加了apoe−/− 小鼠面主动脉和主动脉根部的病变区域（图2 b、c）。 Web14. apr 2024 · Gastric cancer. LINC00511 has been shown to promote progression of gstaric acnecr through regulating SOX4 expression and epigenetically suppressing PTEN to induce activity of PI3K/AKT pathway (Wang et al., 2024).Moreover, LINC00511 can promote growth of gastric tumors through acting as a molecular sponge for miR-124-3p and regulating …
Sox4 chip
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Web27. jan 2024 · Midbrain dopaminergic neurons (mDANs) control voluntary movement, cognition, and reward behavior under physiological conditions and are implicated in human diseases such as Parkinson’s disease (PD). Many transcription factors (TFs) controlling human mDAN differentiation during development have been described, but much of the … Web3. máj 2011 · Tbx3, SOX4, and SOX2 ChIP data, identify a region in intron 1 of Gja1 bound by all tree proteins and subsequent ChIP experiments verify that this sequence is bound, in vivo, in the developing heart. In a luciferase reporter assay, this element displays a synergistic antagonistic response to co-transfection of Tbx3 and Sox4 and in vivo, in ...
Web3. dec 2024 · Genes with a SOX4-binding site within 20 kb of a TSS in MDA-MB-231 cells are annotated in red (C) Normalized ChIP-seq tracks for SOX4, H3K27me3, H3K4me3, POL2, and H3K27ac surrounding the EDN1 locus in HMLE-S4 cells. For histone marks and POL2 both DOX-treated and -untreated profiles are represented (-/+). Web3. aug 2024 · Sox-4 Antibody (B-7) is a mouse monoclonal IgG 1 κ, cited in 6 publications, provided at 200 µg/ml. raised against amino acids 281-370 mapping within an internal …
Web1. júl 2012 · Sox4 is a transcription factor that regulates various developmental processes. Here we show that Sox4 was induced by TGF-β and negatively regulated the transcription … Web15. aug 2024 · The SOXC family consists of three members, SOX4, SOX11, and SOX12, with high sequence and structural homology. To validate SOX11 as a target for development of small-molecule inhibitors, we used microarray analysis to examine the expression levels of SOX4, SOX11, and SOX12 in naïve B cells from five healthy donors and 26 patients with …
Web此外，体外腺病毒介导的sox4过表达在人脐静脉内皮细胞(huvecs)和人主动脉内皮细胞(haecs)中产生了相似的结果。另一方面，sox4的过表达造成了内皮细胞的形态改变以及功能损伤。上述结果提示，sox4具有促动脉粥样硬化的作用，且与sox4介导的endomt有关。
Web16. máj 2024 · In order to determine whether SOX4 binds to the promoter of p65, a CHIP-PCR assay was performed. Our data revealed that SOX4 was able to bind to the p65 promoter at positions +15 to −104, −1490 to −1603, −221 to −318 and −831 to −931 bp. However, the CHIP-PCR assay only indicated that there was a connection between SOX4 … major howell bradyWeb(A, B) Changes in the profiles of SOX4 and RELA ChIP-seq peaks in the Sox4 and Sox11 genomic locus upon TNF treatment. (C) Fold-change Sox4 and Sox11 luciferase reporter activity in HEK293 cells transfected with SOX4 expression plasmids and treated with 10ng/mL TNF for 16h. *p-value < 0.05 by student’s t-test compared to untreated condition. major howellWeb29. sep 2024 · SOX4 plays an important role in the growth and metastasis of breast cancer. SOX4/CXCR7 may serve as potential therapeutic targets for the treatment. Paclitaxel may be a good therapeutic option if the expression level of SOX4 is high. ... The tissue chip slide (ZL-BRM961, SUPERBIOTEK, Shanghai, China), which contained tissues of primary breast ... major hub airports in ohioWeb1. mar 2013 · Sox4-deficient pro-B cells, particularly those expressing the stem cell factor receptor c-Kit, readily underwent apoptosis, and even more so when c-Kit activity was … major hr laws tend to be in the areas of:WebAs shown in Fig. 5a, our Chip-seq data shows that the same region of Gja1 in intron 1 as found in the SOX2 and SOX4 ChIP experiments is also bound by Tbx3, implicating that it may be a conserved ... major hugh lindsay deathWebSOX4 was immunoprecipitated using 0.5mg Mouse Testis tissue, 5µg of Rabbit polyclonal to SOX4 and 50µl of protein G magnetic beads (+). No antibody was added to the control ( … major hughes planetminecraftWeb9. mar 2024 · The target sequence of the transcription factor Sox9 in IESCs was investigated via chromatin immunoprecipitation (ChIP) combined with deep sequencing (ChIP-seq). Increased Sox9 expression is accompanied by the loss of methylation in its promoter in IESCs. ... Sox4, and Fzd8, but also functions as a potential transcriptional inhibitor at a ... major hub airports