Mitf phosphorylation

Author: gnse

August undefined, 2024

Web11 aug. 2010 · MiTF phosphorylation was examined 1 hour after various doses of UVC radiation; as low as 1 mJ/cm 2 of radiation led to MiTF phosphorylation in c83-2C cells (Fig 1D). MiTF phosphorylation is via Erk1/2 mitogen-activated protein kinases (MAPK) and is required for its subsequent proteasome-dependent degradation. WebWe show that mice that carry a BAC transgene where single-amino-acid substitutions have been made in the Mitf gene rescue the phenotype of the loss-of-function mutations in Mitf. This may indicate that. signaling from KIT to MITF affects other phospho-acceptor sites in MITF or that alternative sites can be phosphorylated when Set73 and Ser409 have been …

Microphthalmia Transcription Factor Is a Target of the p38 MAPK …

Web21 feb. 2001 · Loss of phosphorylation and function. 1 publication. Sequence: S → A or P: Mutagenesis: 423: Loss of sumoylation; when associated with R-289. 1 publication. ... 293822 MITF-related melanoma and renal cell carcinoma predisposition syndrome; 319298 Papillary renal cell carcinoma; 42665 Tietz syndrome; More Orphanet links; PharmGKB. WebMITF AKT Phosphorylation TP53 Senescence a b s t r a c t Microphthalmia-associated transcription factor (MITF) plays a crucial role in the melanogenesis and proliferation of melanocytes that is dependent on its abundance and modiﬁcation. Here, we report that epidermal growth factor (EGF) induces senescence and cyclin-dependent kinase ... howliday inn pet resort wv

Emerging roles and regulation of MiT/TFE transcriptional factors

Web9 nov. 2024 · Phosphorylation of p38 evokes Mitf expression, and the interaction between Mitf and NFATc1 is a prerequisite for the expression of TRAP, CTSK, and CTR [23,24,25]. Consequently, suppression of p38 by letrozole can downregulate the expression of TRAP, CTSK, CTR, and DC-STAMP [ 17 , 20 ]. Web13 jan. 2024 · MiTF phosphorylation generally enhances its activity, even though double phosphorylation at Ser73 and Ser409 promotes its proteasome-dependent degradation … WebPhosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence we identified two novel MITF mutations in patients with TS/WS2A. Our results suggest that posterior microphthalmos might be part of the clinical characteristics of Tietz/Waardenburg syndrome type 2A and expand both the clinical and … howliday inn hurricane wv

The underestimated role of the microphthalmia-associated …

Cancers Free Full-Text Acriflavine, a Potent Inhibitor of ... - MDPI

Web2 dagen geleden · The other two transcription factors in the MiT/TFE family, TFE3 and MITF, ... Liu L. Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically? Web26 aug. 2024 · Although the effects of MITF-Ser307 phosphorylation on activity in osteoclasts remain to be investigated further, it has been shown that the phosphorylated … howlie definitionWeb26 dec. 2024 · Previous studies showed that the phosphorylation of ERKs, JNKs, p38, Akt, and S6K upregulated MITF translocation and tyrosinase expression in α-MSH-stimulated B16F10 cells. Therefore, we assume that phosphorylation levels of ERKs, JNKs, p38, Akt, and S6K may be more important for α-MSH-induced melanogenesis. how lic policy surrender value calculated

"Web11 nov. 2024 · ERK phosphorylation has been shown to induce MITF degradation (Song et al., 2015) and lead to the inhibition of melanogenesis. Both PA and EP induced ERK phosphorylation without altering ERK gene expression after 24 hr (Figure 4 a). Treatment of cells with the ERK inhibitor U0126 increased melanogenesis (Figure 4 b,c). " - Mitf phosphorylation

Mitf phosphorylation

A chemical biology approach identifies AMPK as a modulator

Web7 apr. 2024 · On the while, MITF alone is not capable of transactivation of TRP2 (Potterf et al. 2001), and the association of MITF with other transcription factors plays a vital role to activate theTRP2 promoter (Ludwig et al. 2004; Vachtenheim and Borovansky 2010). cAMP plays a key role in MITF expression via phosphorylation of CREB (Roh et al. 2013). Web1 okt. 2009 · It is shown that mice that carry a BAC transgene where single-amino-acid substitutions have been made in the Mitf gene rescue the phenotype of the loss-of …

Did you know?

WebIdentifying the signals regulating tyrosinase and MITF is crucial to understanding how pigmentation responds to extracellular stimuli. In this report, we discovered that … Web31 mrt. 2011 · These findings are consistent with a phosphorylation event (supplemental Figure 4). However, the role of MITF phosphorylation in mediating KIT function in mast …

Web15 mei 2024 · MITF, TFEB, and TFE3 overexpression was also observed in pancreatic adenoductal carcinoma, where they appear to support tumor growth via the induction of autophagy (Perera et al, 2015). MITF is an … Web27 aug. 2024 · Phosphorylation of the melanocyte MITF-M isoform in response to BRAF/MAPK signaling primes for phosphorylation by GSK3, a kinase inhibited by both PI3K and Wnt signaling. Dual phosphorylation, but not monophosphorylation, then promotes MITF nuclear export by activating a previously unrecognized hydrophobic …

Web9 jun. 2024 · Microphthalmia-associated transcription factor-M (MITF-M) is the key gene in the proliferation and differentiation of melanocytes, which undergoes an array of post … Web1 apr. 2006 · Microphthalmia transcription factor (MITF) is a basic helix-loop-helix leucine zipper (bHLH-Zip) DNA-binding protein. 1 Its gene resides at the mi locus in mice, 2 and mutation of this gene results in deafness, bone loss, small eyes, and poorly pigmented eyes and skin. 3 The primary cell types affected in MITF-deficient mice are mast cells, …

WebPhosphorylation of MafA Is Essential for Its Transcriptional and Biological Properties. 2001 • Alain Eychène. Download Free PDF View PDF. Pigment Cell & Melanoma Research. …

Webcould demonstrate that MITF was rapidly and persis-tently phosphorylated upon stimulation of primary os-teoclasts with RANKL and that phosphorylation of Ser307 correlated … how life came into existenceWeb17 dec. 2024 · MITF has three recognized phosphorylation sites: Ser73 (phosphorylated by ERK) , and Ser298 and Ser409 (phosphorylated by GSK3β). MITF phosphorylated at … howliday inn portland oregonWebUltraviolet (UV) radiation exposure is the primary cause of extrinsic skin aging, which results in skin hyperpigmentation and wrinkling. In this study, we investigated the whitening effect of (2E,5E)-2,5-bis(3-hydroxy-4-methoxybenzylidene)cyclopentanone (BHCP) on B16F10 melanoma and its anti-wrinkle activity on Hs27 fibroblasts cells. BHCP was found to … howlies doggy daycareWeb1 aug. 2015 · Thus, the activity of Mitf as a transcription factor appeared to promote its own cytoplasmic sequestration, a phenomenon consistent with increased TORC1 activity in … howliday inn springfield ilWeb30 nov. 2024 · Abstract. The microphthalmia family (MITF, TFEB, TFE3, and TFEC) of transcription factors is emerging as global regulators of cancer cell survival and energy … howliday winter edition draculaura for saleWebAll lanes : Anti-MiTF (phospho S73) antibody (ab59201) at 1/500 dilution Lane 1 : COS-7 (African green monkey kidney fibroblast-like cell line) cell extract Lane 2 : COS-7 (African … howliday monster high dollWeb30 nov. 2014 · The phosphorylation at Ser 73 promotes the interaction with a MITF co-factor, histone acetyl transferase p300/CBP within the transactivation domain of MITF . … how life came about