WebJun 4, 2013 · The structures explain the roles of this tyrosine and of the DH box in DYRK activation and provide a structural model for DYRK substrate recognition. Phosphorylation of a library of naturally occurring peptides identified substrate motifs that lack proline in the P+1 position, suggesting that DYRK1A is not a strictly proline-directed kinase. ... WebJun 15, 2015 · The designation DYRK (for ‘dual-specificity tyrosine (Y) phosphorylation-regulated kinase’) highlights the peculiar biochemical characteristics of this protein kinase family. The hallmark of dual-specificity protein kinases is their ability to phosphorylate aromatic (tyrosine) as well as aliphatic (serine and threonine) amino acid residues.
The chromosome 21 kinase DYRK1A: emerging roles in cancer
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The chromosome 21 kinase DYRK1A: emerging roles in cancer
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