WebNov 1, 2001 · Abstract. Anticancer treatment using cytotoxic drugs is considered to mediate cell death by activating key elements of the apoptosis program and the cellular stress response. While proteolytic enzymes (caspases) serve as main effectors of apoptosis, the mechanisms involved in activation of the caspase system are less clear. WebAug 29, 2016 · We find that hit compounds also show dose-response cytotoxic effects in other non-glioma cancer cell lines indicating that these molecules have potentially broad anti-neoplastic activity. ... (Bip inducer X), which was shown to activate ER stress response elements through the ATF6 pathway but did not induce XBP-1 splicing nor CHOP …
9612 - Gene ResultNCOR2 nuclear receptor corepressor 2 [ (human)]
WebCytotoxic lesions of the corpus callosum are considered a clinical-radiological syndrome that generates transitory damage to the corpus callosum; especially in the splenium, with a multicausal origin such as drugs, malignant neoplasms, infections, subarachnoid hemorrhage, metabolic disorders, and traumas. The clinical presentation varies in ... WebFunctional proteomic screening of chemotherapy-treated breast cancer patient-derived organoids (PDOs) identified nuclear co-repressor-2 (NCOR2) histone deacetylase as … income based disability housing near me
National Center for Biotechnology Information
WebFeb 14, 2024 · Heat-shock proteins (HSPs) play a crucial role in maintaining protein stability for cell survival during stress-induced insults. Overexpression of HSPs in cancer cells results in antiapoptotic activity contributing to cancer cell survival and restricting the efficacy of cytotoxic chemotherapy, which continues to play an important role in the treatment of … WebBesides, cytotoxicity may also result from previously described particle toxicity such as dust overload and oxidative stress, because the release of cytokines, proteases and ROS along with the changes in gene expression can contributing to cytotoxicity [110]. WebTsai KK, Huang SS, Northey JJ, Liao WY, Hsu CC, Cheng LH, Werner ME, Chuu CP, Chatterjee C, Lakins JN, Weaver VM. Screening of organoids derived from patients with … income based dentists near me